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3D printed microreactors uncover new benefits in pharmaceutical synthesis


There are not too many mature cases of microchannels and microreactors applied to domestic chemical production lines. From the perspective of operation and management, the primary demand of microchannel application is to solve the problem of safety and establishment, and the advanced strategic demand is to reduce the reliance on human resources and get more huge benefits from it.


The microchannel 3D printing reactor, jointly developed by Guangdong Academy of Sciences, Dalian Polytechnic University of Chemical Technology and Zhongshan Zhi'an Chemical Technology Co., Ltd. for a large Guangdong company, will be put into operation in Zhuhai in the 3rd quarter of 2021 after a small trial by users, mass production in the production line, running the central control DCS system to achieve proportional chain and automatic operation of the production unit. It is expected that the project will be able to achieve an annual output value of hundreds of millions of yuan and save nearly 10 million yuan of raw material consumption per year after operation.

ZSMR and related technology research and development unit, with pragmatic, innovative, universal multi-functional microreactor to achieve the production of chemically hazardous processes, not limited to oxidation, cyclization, diazotization, chlorination, addition, ammonification, esterification, ammonification and other processes of technological change, with a set of universal micro inverse equipment to replace the traditional multiple kettle reactors.

The project introduced in this paper is a pharmaceutical intermediate, whose value is about RMB 50,000/kg. The mass production data proves that after adopting ZSMR micro-inversion technology, its production unit consumption decreases by 6% compared with traditional equipment and micro-channel equipment, which can directly save nearly 10 million yuan of raw material unit consumption for the company every year.

Zhongshan Zhian microreactor is compatible with all reactions of the same type, and this equipment can also be applied to the synthesis of similar structural chemicals.

As one of the few enterprises engaged in microchemical green synthesis technology in Guangdong Province, Zhongshan Micro Inverse has experienced its 6th year and has so far realized several industrialized pilot projects in China, and the large flux micro inverse projects planned to be landed this year have been implemented one by one.

Microreactor replacement technology, the solution is no longer a concept problem, but really for enterprises to reduce 90% of land input, reduce production quality fluctuations, reduce chemical management pressure, to achieve strategic layout.

ZSMR's unique design concept, relying on the strongest technical team in China, has accumulated and innovated in silicon carbide without sealing surface, corrosion resistant high pressure micro inverse, full range linear metering pump, and high flow micro inverse research.



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